Gene therapy and peripheral nerve repair: a perspective
نویسندگان
چکیده
منابع مشابه
Gene therapy and peripheral nerve repair: a perspective
Clinical phase I/II studies have demonstrated the safety of gene therapy for a variety of central nervous system disorders, including Canavan's, Parkinson's (PD) and Alzheimer's disease (AD), retinal diseases and pain. The majority of gene therapy studies in the CNS have used adeno-associated viral vectors (AAV) and the first AAV-based therapeutic, a vector encoding lipoprotein lipase, is now m...
متن کاملPeripheral nerve injury and repair.
Peripheral nerve injuries are common, and there is no easily available formula for successful treatment. Incomplete injuries are most frequent. Seddon classified nerve injuries into three categories: neurapraxia, axonotmesis, and neurotmesis. After complete axonal transection, the neuron undergoes a number of degenerative processes, followed by attempts at regeneration. A distal growth cone see...
متن کاملPeripheral Nerve Injury: Stem Cell Therapy and Peripheral Nerve Transfer
Peripheral nerve injury can lead to great morbidity in those afflicted, ranging from sensory loss, motor loss, chronic pain, or a combination of deficits. Over time, research has investigated neuronal molecular mechanisms implicated in nerve damage, classified nerve injury, and developed surgical techniques for treatment. Despite these advancements, full functional recovery remains less than id...
متن کاملPeripheral Nerve Regeneration: A Current Perspective
OBJECTIVE Nerve regenerative is a complex problem and cell therapy strategies are being developed to enhance axonal regeneration. One approach is to transplant peripheral myelin-forming cells (Schwann cells or olfactory ensheathing cells) that can secrete neurotrophic factors and participate in remyelination of regenerated axons. The objectives of this report are to first review the basic regen...
متن کاملTiming and technique of peripheral nerve repair.
Surgery of the peripheral nerves is briefly reviewed with special emphasis on the timing and the techniques of nerve repair. The sooner a severed nerve can be repaired, the better the quality of the recovery. While delays of a few months after injury appear to have no serious effect on the out come of nerve sutures, the chances of successful recovery decline after six months. It is not common f...
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ژورنال
عنوان ژورنال: Frontiers in Molecular Neuroscience
سال: 2015
ISSN: 1662-5099
DOI: 10.3389/fnmol.2015.00032